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Cholera outbreaks occur when there is a breakdown in sanitation, leading to contamination of food and water. Although antibiotics may speed recovery and reduce the organism's spread, limiting their use is now recommended because of potential resistance development. Therefore, other approaches are urgently needed. One alternative is use of bacteriophages (phages), which have been used successfully in various experimental animal systems and in some human infections.
In this study, among 12 phages tested, one, vB_VchoP_1 (Phi_1), had a broad host range and a low risk of inducing lysogeny, making it suitable for further assessment. Infant rabbits were orally infected with Vibrio cholerae followed 6 hours later by Phi_1. Watery stool and cecal fl…