Hypertension in Late Adolescence Might Increase Risk for End-Stage Renal Disease

In otherwise healthy adolescents with persistent hypertension at age 16 to 19 years, long-term risk for developing ESRD was doubled.

The long-term implications of adolescent hypertension for the later development of end-stage renal disease (ESRD) is an unresolved and important question. In the current retrospective review of over 2.6 million healthy men and women recruited for the Israeli military at ages 16–19 years, researchers compared the risk for future ESRD between nonhypertensive and persistently hypertensive adolescents.

In all, 7997 individuals (90% men and 49% obese or overweight) were identified with persistent hypertension (>140/90 mm/Hg), and 95 had severe hypertension (>160/100 mm/Hg). After a median follow-up of 20 years, 0.5% of the hypertensive adolescents (42 cases) and 0.1% of normotensive recruits developed ESRD (crude hazard ratio, 5.1). The unadjuste…

Reviewing Author

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

Hypertension in Late Adolescence Might Increase Risk for End-Stage Renal Disease

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Reviewing Author