Maternal Diabetes Type, Prepregnancy BMI, and Adverse Birth Outcomes

Insulin-treated diabetes, especially in overweight or obese women, was associated with the highest risks for large-for-gestational age and premature births.

Fetal exposure to hyperglycemia affects birth weight. Overweight and obesity are also associated with offspring being large for gestational age (LGA) or born prematurely. To examine the interactions between prepregnancy body-mass index (BMI) and different maternal diabetes diagnoses in contributing to prematurity and LGA risks, researchers examined data from 650,000 live births in Finland between 2004 and 2014. Results included the following:

Insulin-treated diabetes conferred high risks for LGA and prematurity independent of prepregnancy BMI (adjusted overall odds ratios: 44 for LGA; 11 for prematurity).
Non–insulin-treated type 2 diabetes was associated with a doubled risk for prematurity regardless of BMI, and risk for LGA increased with i…

Reviewing Author

Catherine M. Gordon, MD, MSc

Disclosures

Consultant/Advisory BoardEli Lilly and Company; Advisory Council, Eunice Kennedy Shriver National Institute of Child Health and Human Development; Subboard for Adolescent Medicine, American Board of Pediatrics

Grant/Research SupportPatty Brisben Foundation

Editorial BoardsOsteoporosis International; Bone; Journal of Adolescent Health

Catherine M. Gordon, MD, MSc

Disclosures

Grant/Research SupportPatty Brisben Foundation

Editorial BoardsOsteoporosis International; Bone; Journal of Adolescent Health

Maternal Diabetes Type, Prepregnancy BMI, and Adverse Birth Outcomes

Topics

Reviewing Author