Post–Lung Transplant Fungal Disease

At a major transplant center, invasive fungal infection was common after lung transplant, and was not fully prevented by antifungal prophylaxis.

Lung transplant recipients are prone to developing invasive fungal infection (IFI); a prospective, multicenter study from 2001–2006 reported an IFI incidence during the first postop year of 8.6% (Clin Infect Dis 2010; 50:1101). How transplant centers approach this problem varies considerably. Researchers at Duke University did a retrospective analysis of 815 consecutive lung transplants carried out between 2007 and 2014. All patients received antifungal prophylaxis consisting of a short course of aerosolized amphotericin B lipid complex, with or without an antimold triazole drug or micafungin.

Overall, 156 transplant recipients (19%) developed IFI within the first 180 days after transplantation, with either Candida species (57% of episodes) …

Reviewing Author

Stephen G. Baum, MD

Disclosures

Consultant/Advisory BoardClinical Infectious Diseases

RoyaltiesUpToDate

Editorial BoardsMedical Letter

Stephen G. Baum, MD

Disclosures

Consultant/Advisory BoardClinical Infectious Diseases

RoyaltiesUpToDate

Editorial BoardsMedical Letter

Post–Lung Transplant Fungal Disease

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Reviewing Author