Should Perioperative Antibiotics at Myomectomy Be Universal?

Perioperative antibiotics are recommended for many gynecologic procedures, but not for cases involving operative laparoscopy (Obstet Gynecol 2018; 131:e172). Although >30,000 myomectomies are performed in the U.S. each year, no high-quality studies have examined the use of perioperative antibiotics in such cases. In this retrospective cohort study of women undergoing myomectomy, investigators evaluated patterns of antibiotic use at two academic hospitals over a 7-year period. Cases managed with vaginal or hysteroscopic myomectomy, chromopertubation, or conversion to hysterectomy were excluded. Surgical-site infection was defined as infection occurring within 30 days of surgery and involving the surgical incision(s), organ, or space.

Among 12…