Cognitive Trajectories Associated with Amyloid and Tau Profiles in CSF

Amyloid and tau profiles may identify cognitively normal adults at increased risk for cognitive decline.

Low amyloid and high tau levels in the cerebrospinal fluid (CSF) have been associated with Alzheimer disease (AD). Two schemas to classify these biomarkers include National Institute of Aging-Alzheimer's Association/suspected non-AD pathology (NIA-AA/SNAP) and the amyloid-tau-neurodegeneration (ATN) frameworks. Investigators conducted an analysis of 814 cognitively normal participants (mean age, about 60; 63% female; mean education, 16 years) from four cohort studies with baseline measurements of CSF β-amyloid 1-42 (A), phosphorylated tau 181 (p-tau₁₈₁; T) as a marker for tangle pathology, and total tau as a marker for neurodegeneration (t-tau; N). Cognitive performance was assessed every 12 to 18 months via a global cognitive factor score …

Reviewing Author

Jennifer Rose V. Molano, MD

Disclosures

Grant/Research SupportNational Center for Advancing Translational Science – Cincinnati Center for Clinical and Translational Science and Training

Editorial BoardsBrain & Life

Jennifer Rose V. Molano, MD

Disclosures

Grant/Research SupportNational Center for Advancing Translational Science – Cincinnati Center for Clinical and Translational Science and Training

Editorial BoardsBrain & Life

Cognitive Trajectories Associated with Amyloid and Tau Profiles in CSF

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Reviewing Author