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In vitro fertilization (IVF) has been associated with increased risk for structural birth defects and genomic imprinting disorders in the offspring; is incidence of childhood cancer also increased? Investigators conducted a retrospective study using data on IVF cycles and live births in 14 U.S. states from 2004 through 2012. More than 275,000 children conceived with IVF were randomly matched 1:10 with >2,266,000 children conceived without IVF. Mothers in the IVF group were older, more educated, and more often white; their children had lower mean birth weight, shorter gestation, and were more often multiple births.
During a mean follow-up of 4.5 years, 321 and 2014 cancers occurred among offspring in the IVF and comparator groups, respectivel…