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Although the causes of most biliary strictures are obvious (e.g., pancreatic cancer or surgical injury), some are indeterminate. In these instances, it is critical to definitively diagnose or rule out malignancy, usually cholangiocarcinoma.
To determine whether next-generation sequencing (NGS) multigene analysis of biliary samples can increase diagnostic yield in this setting, investigators conducted a retrospective study of 252 patients with bile duct strictures, including 41 with primary sclerosing cholangitis (PSC), the most commonly encountered group with indeterminate biliary strictures. A total of 163 biliary brushings and 172 biliary biopsies were used for pathological evaluation, and 160 brushings and 135 biopsies were used for NGS t…