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Although metformin has short-term weight-loss benefits, less is known about its ability to sustain long-term weight loss. Using data from the Diabetes Prevention Program Outcomes Study (which involved >2700 prediabetic, obese or overweight participants who were randomized to receive metformin, intensive lifestyle intervention, or placebo; NEJM JW Gen Med Mar 15 2002 and N Engl J Med 2002; 346:393; NEJM JW Gen Med Jan 15 2010 and Lancet 2009; 374:1677), investigators evaluated ≈1000 participants who had lost at least 5% of their baseline weight within the first year. Twenty-nine percent of the metformin group, 63% of the lifestyle-intervention group, and 13% of the placebo group had lost the weight required to be included in this post hoc an…