Preeclampsia as a Harbinger of Maternal Renal Disease

Preeclampsia is a systemic pregnancy-related condition associated with multiple organ system dysfunction, including renal malfunction. Earlier reports suggested excess risk for subsequent renal disease among patients with preeclampsia, but other findings have been inconsistent. Using a nationwide health database, Danish investigators followed a cohort of >1 million pregnant women from 1978 through 2015.

During a mean follow-up of 18.6 years per woman, 3901 cases of chronic renal disease were identified. Risk for subsequent chronic renal disease was more than doubled in women with a history of preeclampsia compared with those delivering at comparable gestational ages without preeclampsia. Among women with a history of preeclampsia associated …