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Vitamin D levels correlate with better cancer outcomes in observational studies, and cellular and molecular studies suggest that vitamin D might have anticancer effects. Now, in two new trials, researchers evaluated whether vitamin D has therapeutic effects in cancer patients.
In a Japanese study, 417 patients with digestive-tract cancers who underwent potentially curative surgical resections were randomized to receive either 2000 IU of vitamin D3 or placebo daily. During median follow-up of 3.5 years (maximum follow-up, 7.5 years), neither estimated relapse-free survival nor overall survival differed significantly in the two groups.
In a U.S. study, 139 patients with metastatic colorectal cancer who underwent chemotherapy were randomized to …