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Substance use disorders in adolescents, particularly cannabis use disorders, frequently precede diagnoses of schizophrenia. To study how substance-induced psychosis (SIP) might progress to schizophrenia, investigators used Swedish national registries to prospectively track 7606 individuals (age range, 15–50; mean, 32; 78% male) diagnosed with SIP (most commonly, alcohol [28%]; stimulants [22%]; cannabis [13%]; multiple/other [31%]). Diagnoses of alcohol use disorder, drug abuse, and nonaffective psychosis in first-, second-, and third-degree relatives were ascertained concurrently. Mean follow-up after SIP diagnosis was 84 months.
Not surprising, SIP was associated with elevated familial risks for alcohol or substance abuse; familial risk wa…