When the HIV-positive partner is virally suppressed on ART, risk for HIV transmission is zero.
Emerging data suggest risk for sexual HIV transmission among heterosexual couples is low when the HIV-positive partner is virally suppressed on antiretroviral therapy (ART; NEJM JW Infect Dis Sep 2016 and N Engl J Med 2016; 375:830). Although data also suggest this is true among men who have sex with men (MSM), the confidence interval in the PARTNER study did not exclude the possibility of transmission (NEJM JW Infect Dis Aug 2016 and JAMA 2016; 316:171).
In PARTNER2, investigators sought precise estimates of sexual transmission risk among 972 gay male couples in 14 European countries. Couples were enrolled if they were serodiscordant, the HIV-positive partner was on ART, they had recent condomless penetrative sex, and the HIV-negative partn…
Reviewing Author
DisclosuresGrant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; NIH/National Institute on Drug Abuse
Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes; Vaccines
Leadership Positions in Professional SocietiesInternational Antiviral Society–USA (Board of Directors); Infectious Diseases Society of America (Past President)
DisclosuresGrant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; NIH/National Institute on Drug Abuse
Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes; Vaccines
Leadership Positions in Professional SocietiesInternational Antiviral Society–USA (Board of Directors); Infectious Diseases Society of America (Past President)