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Since the 1990s, hepatocellular carcinoma (HCC) rates have steadily increased worldwide. However, during the last decade, these rates have plateaued and even declined in certain parts of the world such as Asia, possibly due to an increase in hepatitis B virus vaccination and other public health interventions. It is unclear if this trend is also occurring in the United States.
Using U.S. cancer registry data, researchers examined changes in HCC incidence rates in 10-year age groups by sex and race/ethnicity from 1992 to 2015. During this period, about 50,000 new cases of HCC were diagnosed. The overall incidence rate was 7.7 per 100,000, increasing from 4.1 in 1992 to 9.5 in 2015. Incidence increased from 1992 to 2010 and began plateauing the…