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There is increasing evidence that minimally invasive surgery for gastric cancer is safe and feasible in both early-stage and more locally advanced disease. Minimally invasive surgery may reduce operative morbidity, recovery time, and length of hospital stay. A prior report of the CLASS-01 trial, a multicenter, randomized, noninferiority trial conducted in China comparing laparoscopic versus open distal gastrectomy, indicated the safety and feasibility of performing laparoscopic gastrectomy for locally advanced T2-4aN0-3 gastric cancer (NEJM JW Oncol Hematol Jul 2016 and J Clin Oncol 2016; 34:1350).
Investigators now report 3-year disease-free survival (DFS) results from CLASS-01, the primary endpoint of the trial. Of the 1056 patients random…