Preventing Type 1 Diabetes with Teplizumab

An anti-CD3 antibody therapy significantly delayed onset of clinical diabetes in an at-risk population with diabetes autoantibodies.

Because type 1 diabetes mellitus (DM) is the result of immune destruction of pancreatic islet cells, immunologic interventions have shown promise in delaying its onset. In a phase II, international, randomized, placebo-controlled trial, researchers tested the efficacy of a 14-day regimen of intravenous teplizumab, an anti-CD3 antibody, for delaying the development of clinical DM in 76 at-risk participants. Most were children (ages 8–18; median age, 13–14 years) and white. All had a relative with DM, at least two DM-related autoantibodies, and recent abnormal glucose tolerance tests.

The median time to diagnosis of clinical DM was 48 months in the teplizumab group compared with 24 months in the placebo group (P=0.006). DM developed at an annu…

Reviewing Author

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

Preventing Type 1 Diabetes with Teplizumab

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Reviewing Author