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The emergence of methicillin-resistance Staphylococcus aureus (MRSA) has had negative effects on clinical outcomes of S. aureus bloodstream infections. Vancomycin, the cornerstone of MRSA therapy, lacks the favorable adjunctive properties (enhancement of bacterial killing by innate immunity) of β-lactams, which are used to treat methicillin-susceptible S. aureus (MSSA). Researchers previously showed that antimicrobial susceptibility testing is more predictive of antibiotic activity in vivo when the testing includes bicarbonate, which maintains pH stability in vivo. In this study, the same researchers have now examined the susceptibility of five MRSA genotypes to the β-lactams oxacillin and cefazolin, using media lacking or containing sodium…