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Patients with first-episode schizophrenia demonstrate baseline cognitive deficits relative to peers, but little is known about long-term changes in patients with schizophrenia and other psychoses. Investigators in a U.K. population-based, longitudinal study conducted neuropsychological assessments in 187 patients with first-episode psychosis and 177 healthy controls.
Assessments included full-scale IQ, memory, verbal knowledge, executive function/working memory, processing speed, and visuospatial abilities. At baseline in adjusted analyses, patients with schizophrenia and other psychoses had lower IQ and widespread cognitive impairment (11 of 14 measures) compared to controls. Patients with schizophrenia showed greater impairment than those …