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Depression and anxiety, both as symptoms and as formal disorders, are elevated in patients with chronic medical disorders, including obstructive sleep apnea, for which continuous positive airway pressure (CPAP) treatment is the standard of care. To study the relationship of CPAP to depressive and anxiety symptoms, investigators performed a secondary analysis of data from an international, randomized, controlled, prospective study examining the effectiveness of CPAP treatment for secondary prevention of cardiovascular disease in 2410 participants (baseline mean age, 61; mean body-mass index, 28.6 kg/m2; men, 81%; Asian, 63%).
In addition to coronary artery disease (55%) and cerebrovascular disease (50%), comorbidities included hypertension (7…