Tracking Pregnancy Outcomes Among Women with Systemic Lupus Erythematosus

Despite improvements over the years, SLE still brings excess risk for severe maternal morbidity.

Systemic lupus erythematosus (SLE) primarily affects women of reproductive age, yet relatively little is known about its effect on pregnancy outcomes in real-world practice. Investigators used the National Inpatient Sample database to assess pregnancy outcomes in some 94,000 U.S. women with SLE and 78,000,000 without SLE from 1998 to 2015.

Women with SLE had higher rates of in-hospital maternal mortality (180 vs. 12 deaths per 100,000 admissions), fetal mortality (180 vs. 65 deaths per 10,000 deliveries), preeclampsia or eclampsia (8.8% vs. 3.5% of pregnancies), and cesarean delivery (40% vs. 29%). In-hospital maternal death rates per 100,000 admissions for women with SLE were 442 (1998−2000) and <50 (2013−2015), suggesting a decline in risk…

Reviewing Author

Robert L. Barbieri, MD

Disclosures

Grant/Research SupportNational Institutes of Health

Editorial BoardsUpToDate

Robert L. Barbieri, MD

Disclosures

Grant/Research SupportNational Institutes of Health

Editorial BoardsUpToDate

Tracking Pregnancy Outcomes Among Women with Systemic Lupus Erythematosus

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Reviewing Author