Elevated Lipoprotein(a) and Cardiovascular Disease: More Evidence of a Causal Link

Ischemic stroke risk was associated with Lp(a) levels and LPA gene variants in a contemporary Danish population study.

Lipoprotein(a) [Lp(a)] is increasingly recognized as an important risk factor for atherosclerosis. Lp(a) levels are primarily genetically determined and remain stable over time. Using data from the contemporary Copenhagen General Population Study (n=49,699) and the historical Copenhagen City Heart Study (n=10,813), investigators explored whether elevated Lp(a) is associated with increased risk for ischemic stroke. Additionally, they analyzed potential links between stroke risk and two LPA genotype variants (LPA KIV-2 number of repeats and presence of LPA rs10455872).

In the contemporary cohort, individuals with the highest Lp(a) levels (>93 mg/dL) had 1.6 times the adjusted risk for ischemic stroke as those with the lowest levels (<10 mg/dL)…

Reviewing Author

Fatima Rodriguez, MD, MPH, FACC, FAHA

Disclosures

Consultant/Advisory BoardNovoNordisk; HealthPals; Novartis; Amgen

EquityHealthPals; Carta

Grant/Research SupportNational Institutes of Health/National Heart, Lung, and Blood Institute; American Heart Association–Robert Wood Johnson Foundation

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