Risk Factors for Gastric Cancer in Lynch Syndrome Patients

The cumulative risk for gastric cancer in patients with Lynch syndrome (LS) is estimated to be 7% to 8%. However, there are sparse data regarding risk factors and the impact of screening on patient outcomes, resulting in disparate guideline recommendations. For example, the U.S. Multi-Society Task Force states that screening for gastric cancer should be “considered” with biopsy of the gastric antrum at age 30 to 35 years with subsequent endoscopic surveillance every 2 to 3 years based on individual patient risk factors, whereas European guidelines recommend screening in all LS carriers with Helicobacter pylori testing and esophagogastroduodenoscopy (EGD) every 1 to 2 years, beginning no later than age 30.

Now, investigators have conducted a …