Modeling Adherence Levels Needed to Achieve 90% HIV Suppression Rates

An adherence rate of 82% was estimated to result in a 90% viral suppression rate, in a model based on pharmacy refill and HIV RNA level data.

Clinicians and pharmacists generally encourage patients with HIV to achieve a 100% adherence rate for their antiretroviral medications. The actual rate needed for viral suppression in the modern era has not been well delineated. To provide data, researchers tracked HIV-positive persons treated by HIV clinicians partnered with HIV-specialty pharmacies from August 2014 to September 2016. This analysis focused on a proxy of adherence, the proportion of days covered (PDC; dividing the days of antiretroviral therapy included in last prescription by the days since last refill) and HIV RNA levels linked timewise to the refill periods (for this study, HIV RNA levels <200 copies/mL were considered suppressed).

Of 765 participants, 570 had ≥1 HIV RNA …

Reviewing Author

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Modeling Adherence Levels Needed to Achieve 90% HIV Suppression Rates

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Reviewing Author