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Previous studies have suggested a link between obesity and multiple sclerosis (MS) in childhood (NEJM JW Neurol Mar 2013 and Neurology 2013; 80:548). German investigators evaluated obesity within a pediatric population at a single center. Comparing body-mass index (BMI) in 453 children with MS (mean age at diagnosis, 14 years) with BMI standards for healthy children in Germany, risk for MS was 2.2-fold higher among those who were obese and 1.4-fold higher for those who were overweight. Among the 352 patients who received a disease-modifying therapy, those who were obese had higher relapse rates on treatment than those with lower BMI. Those who were extremely obese had the highest on-therapy relapse rates. Among 181 patients with ≥12-month f…