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The multitarget stool DNA (mt-sDNA) test is a highly sensitive, noninvasive colorectal cancer screening option for average-risk individuals. However, there is uncertainty about whether patients with a positive stool DNA test result but negative colonoscopy are at increased risk for cancer and therefore require additional scrutiny and evaluation.
To explore this issue, investigators conducted a retrospective, multicenter, cohort study of 1216 patients with negative screening colonoscopies (no neoplasia or only nonadvanced adenomas) and either negative (concordant) or positive (discordant) mt-sDNA results. The researchers compared the incidence of subsequent aerodigestive cancers with expected incidence based on Surveillance, Epidemiology, and…