Can Endoscopic Remodeling of the Duodenum Treat Type 2 Diabetes Mellitus?

A small multicenter study shows durable improvement in T2D indicators at 1 year after endoscopic duodenal mucosal resurfacing.

Exclusion of the duodenum through bariatric surgery has shown immediate benefit of improved glycemic control, independent of weight loss, in obese patients with type 2 diabetes mellitus (T2D). Endoscopic duodenal mucosal resurfacing (DMR) — a new minimally invasive technique that involves circumferential hydrothermal ablation of the postampullary duodenal mucosa — might present a novel approach to improving glycemic control in T2D.

To test the efficacy and safety of DMR in this setting, researchers conducted an industry-funded, multicenter, prospective, single-arm trial in 46 patients on stable T2D treatment who underwent DMR. Body-mass index of patients ranged from 24 to 40. There were 36 patients included in the per-protocol analysis; drop…

Reviewing Author

John R. Saltzman, MD

Disclosures

Consultant/Advisory BoardIterative Scopes

Editorial BoardsGastrointestinal Endoscopy; UpToDate

Leadership Positions in Professional SocietiesAmerican College of Gastroenterology (Trustee)

OtherVice President of Medical Affairs, 1Globe Health Institute