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Neisseria gonorrhoeae has developed increasing antimicrobial resistance, prompting a need for novel treatment strategies. One approach is antimicrobial blue light (aBL; wavelength, 405 nm), which has intrinsic antimicrobial activity without the need for photosensitizers.
To test whether aBL could be a possible therapy, researchers demonstrated a 6-log10 reduction among five strains of N. gonorrhoeae at radiant energies of ≤108 J/cm2. No development of resistance was seen with up to 15 exposures. The effect was significantly reduced in the presence of 10 mM NaN3, which may have quenched singlet oxygen generation from bacterial coproporphyrin. Similarly exposed vaginal epithelial cells demonstrated minimal toxicity. When N. gonorrhoeae-infecte…