Renal Scarring in Children with Febrile Urinary Tract Infections

Few children develop scarring after a single febrile UTI, but more than 25% do so after two or more episodes.

A goal of managing febrile urinary tract infections (UTIs) in children is to avoid renal scarring. To determine when scarring occurs in this setting, investigators conducted a post hoc analysis of 345 children with febrile UTIs (mean age, 19.4 months; 89% girls; 64% with vesicoureteral reflux) who were involved in the prospective, multicenter RIVUR and CUTIE studies (N Engl J Med 2014; 370:2367 and Pediatrics 2015; 136:e13, respectively); children from these studies who had no preexisting renal scars or antibiotic prophylaxis were included in the current analysis. The researchers assessed technetium 99m dimercaptosuccinic acid kidney scans of the children obtained within 16 weeks of each febrile UTI episode and after 2 years.

Results were as…

Reviewing Author

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

Renal Scarring in Children with Febrile Urinary Tract Infections

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Reviewing Author