Anti-Interferon-γ Immunodeficiency Syndrome

This condition, rare in Asia and rarer in the U.S., is associated with opportunistic nontuberculous mycobacterial and other infections.

These researchers describe the natural history of a syndrome, first reported in 2004, in which the presence of autoantibodies to interferon-γ (IFN-γ) creates an immunodeficiency state associated with opportunistic infections comprised mostly of nontuberculous mycobacteria (NTM). The investigators followed up on 74 patients (median follow-up duration, 7.5 years) at a single medical center in Thailand and 23 patients at the National Institutes of Health in the U.S. (19 followed by chart review for a median of 4.5 years).

All patients seen in Thailand were of Southeast Asian descent; 64% were female. Of the U.S. patients, 91% were of Southeast Asian descent, 9% were U.S.-born Caucasians, and 91% were female. Other differences included preponder…

Reviewing Author

Stephen G. Baum, MD

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Consultant/Advisory BoardClinical Infectious Diseases

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Editorial BoardsMedical Letter

Stephen G. Baum, MD

Disclosures

Consultant/Advisory BoardClinical Infectious Diseases

RoyaltiesUpToDate

Editorial BoardsMedical Letter

Anti-Interferon-γ Immunodeficiency Syndrome

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Reviewing Author