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Guidelines recommend that clinicians treat patients with hypothyroidism to normalize thyroid-stimulating hormone (TSH) concentration (Thyroid 2014; 24:1670). However, the normal TSH range is broad (0.4–4.0 mIU/L). In this study, researchers used a U.K. primary care database to determine whether maintaining TSH concentrations across or outside of the normal range was associated with adverse outcomes in 160,000 adults with newly diagnosed hypothyroidism (mean age at diagnosis, 58).
TSH levels were measured an average of 5 times per patient during median follow-up of 6 years. After adjustment for multiple variables, rates of all-cause death, CV disease, and fractures were similar in all patients whose TSH concentrations were maintained anywhere…