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While clinicians are aware that some remitted depressed patients have persisting cognitive impairment, the frequency, characteristics, and severity of this impairment, as well as its moderators, have not been comprehensively assessed. These researchers conducted a meta-analysis of 252 studies over the past 5 decades that compared 75 cognitive variables in patients with remitted depression (largely unipolar; n=11,882) and healthy controls (n=8533).
No specific profile of deficits was identified. Between-group cognitive differences on 52 variables had significant small-to-medium effect sizes; three memory variables showed larger effects. Deficits were greater in people with a higher number of depressive episodes. In the small group of studies …