How Can Gastric Cancer Incidence and Mortality Be Reduced?

A long-term study shows benefits of H. pylori eradication and supplementation with vitamins and garlic.

Helicobacter pylori is a known risk factor for gastric cancer, and its eradication may be protective against the disease. Both garlic and vitamin supplementation may also be protective in populations with nutritional deficiencies.

To ascertain the effects of H. pylori eradication, vitamin supplementation, and garlic supplementation on gastric cancer incidence and mortality, investigators conducted a randomized, placebo-controlled trial involving 3365 people living in China in a high-risk area for gastric cancer. The 2258 participants with H. pylori infection were assigned in a 2×2×2 factorial fashion to H. pylori eradication treatment, supplementation with vitamins (vitamins C, E, and selenium), or supplementation with garlic (extract and oi…

Reviewing Author

John R. Saltzman, MD

Disclosures

Consultant/Advisory BoardIterative Scopes

Editorial BoardsGastrointestinal Endoscopy; UpToDate

Leadership Positions in Professional SocietiesAmerican College of Gastroenterology (Trustee)

OtherVice President of Medical Affairs, 1Globe Health Institute