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The effects of rapidly versus slowly increasing milk volumes to reach full feeding in very premature neonates remains unclear. In a multinational study of 2470 preterm neonates (gestational age <32 weeks or birth weight <1500 g), researchers compared 24-month neurocognitive outcomes between neonates randomized to daily increases in milk volume of either 30 or 18 mL/kg. Most children received breast milk, alone or with formula; only 70 received formula alone.
Median gestational age was 29 weeks. Approximately 95% of participants in each group survived to 24 months (corrected for gestational age). There was no significant difference in the rate of moderate or severe neurodevelopmental disability between the rapid- and slow-increment groups (31…