Risk-Based Colorectal Cancer Screening

A guideline suggests no screening for individuals aged 50 to 79 years with an estimated 15-year colorectal cancer risk below 3%.

Sponsoring Organization: BMJ Rapid Recommendations — A collaboration between the MAGIC group and the BMJ

Background and Objective

Professional organizations offer divergent recommendations with regard to age, modality, and frequency of screening for colorectal cancer (CRC). The aim of this guideline was to assess the 15-year benefits, burdens, and harms of CRC screening with annual or biennial fecal immunochemical test (FIT), a single sigmoidoscopy, or a single colonoscopy in individuals 50 to 79 years old with no prior screening. The guideline developers conducted a systematic literature review and microsimulation modeling.

Key Recommendations

No CRC screening is suggested for individuals with a 15-year CRC risk below 3%, as estimated by the Q…

Reviewing Author

Charles J. Kahi, MD, MS

Disclosures

Grant/Research SupportU.S. Department of Veterans Affairs (VA) HSR&D; VA Cooperative Studies Program; VA QUERI

Editorial BoardsClinical Gastroenterology and Hepatology; AGA Perspectives