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Shortening the duration of mechanical ventilation has many benefits, including lowering risks for ventilator-associated pneumonia and delirium. Clinicians usually attempt extubation as soon as possible, with the knowledge that some extubated patients will require reintubation. In patients where risk for reintubation is particularly high, immediate support with noninvasive ventilation (NIV) or high-flow nasal cannula (HFNC) oxygen has been studied, but no clear “best practice” has been established.
Investigators in France randomized 641 patients at high risk for extubation failure (i.e., age, >65 or underlying cardiac or pulmonary disease) to 48 hours of either HFNC alone or NIV plus HFNC during breaks from NIV. Reintubation criteria were pro…