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After transfusing 1 unit of packed red blood cells (RBCs), physicians expect a 1 g/dL incremental increase in the hemoglobin. Prior research has focused on transfusion efficacy based on blood-donor characteristics as well as blood-product collection, preparation, and storage. However, researchers postulated that there may be an important interplay between these factors and transfusion recipient characteristics.
To test this hypothesis, investigators linked data from 23,194 individuals who received RBC transfusions with donor demographic data and blood component characteristics. The primary outcome was change in hemoglobin increment after a single-unit RBC transfusion. Results were as follows:
Larger hemoglobin increments were observed in reci…