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Neuropsychiatric symptoms in those with dementia can be challenging to treat. Researchers conducted a systematic review and network meta-analysis of 163 randomized, controlled trials to compare the effects of nonpharmacologic and pharmacologic interventions on aggression and agitation in those with dementia.
Most studies had a mean patient age of ≥70 years, at least 50% women, and a duration of less than 11 weeks. Of the included studies, dementia type was not specified in 37% and 28% focused on Alzheimer disease. Dementia severity was not reported in 43% of the studies, mild/moderate/severe dementia was included in 27% of the studies, and moderate/severe dementia was the focus in 20% of the studies.
For physical or verbal aggression, modific…