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In 2015, investigators in South Africa reported the results of the first cohort of patients with HIV who received kidney transplants from deceased donors with HIV. The current report describes longer-term results in 51 transplants performed from 2008 to 2018.
Five-year survival and graft survival were 83% and 79%, respectively. Serum and peripheral blood mononuclear cell samples from 15 donors and 26 recipients transplanted after 2011 were further evaluated. Deep sequencing revealed no evidence of donor-derived drug resistance mutations (DRMs) in the recipients. However, no donors had any DRMs at physiologically relevant levels (>0.05%). Eight recipients had evidence of donor virus in the earliest available plasma sample (1 to 6 weeks after …