Endoscopic Management of Patients with Lynch Syndrome or Familial Colorectal Cancer Risk

A new European guideline is similar to U.S. guidelines but utilizes a more-restrictive definition of familial CRC risk.

Sponsoring Organization: European Society of Gastrointestinal Endoscopy (ESGE)

Background and Objective

Because of the increased risk for cancer in patients with Lynch syndrome (LS) or familial colorectal cancer risk and their relatives, prompt recognition by clinicians is crucial to implement appropriate screening and management. This new guideline provides recommendations on the endoscopic management of these groups of patients.

Key Recommendations

Follow patients with LS in specialized units (national registries, genetic counseling centers, or high-risk cancer centers) where adherence to surveillance recommendations and quality are monitored.
Start colonoscopy surveillance in patients with LS at age 25 for MLH1 and MSH2 mutation carriers and …

Reviewing Author

Charles J. Kahi, MD, MS

Disclosures

Grant/Research SupportU.S. Department of Veterans Affairs (VA) HSR&D; VA Cooperative Studies Program; VA QUERI

Editorial BoardsClinical Gastroenterology and Hepatology; AGA Perspectives