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Historically, the lack of available human leukocyte antigen (HLA)–matched donor cells has constrained allogeneic stem cell transplantation (SCT). To overcome this limitation, HLA-haploidentical donor cells from a sibling, parent, or child are used, after which high-dose cyclophosphamide is administered. However, concerns have been raised about the effectiveness of this approach versus other transplant strategies.
To further evaluate this procedure, investigators conducted a retrospective meta-analysis of 30 studies involving 22,974 adults with hematologic malignancies who underwent haploidentical SCT versus other transplant strategies; one study was a prospective phase II trial, and 29 were retrospective studies. The comparators included hap…