Managing Pregnancy in Women with Myeloproliferative Neoplasms

Aspirin and interferon improved live birth rates among pregnant women with essential thrombocythemia or polycythemia vera.

Myeloproliferative neoplasms (MPNs) are typically diagnosed later in adulthood, but some patients with essential thrombocythemia (ET) and polycythemia vera (PV) present before the age of 40. For younger women with MPNs, pregnancies are high risk, and multidisciplinary collaboration is required, yet hematologists have scarce data to support recommendations.

Now, investigators have conducted a meta-analysis of 22 studies involving 1210 pregnancies among 767 women with MPNs to determine whether treatments with low-molecular-weight heparin (LMWH), aspirin, and interferon improved outcomes. Of these studies, 15 included women with ET, 3 included women with PV, and 4 included women with any classical MPN; 19 studies were retrospective.

Key findings…

Reviewing Author

Brady L. Stein, MD, MHS

Disclosures

Leadership Positions in Professional SocietiesAmerican Society of Hematology (Senior Editor, ASH Self-Assessment Program; guideline development)

Brady L. Stein, MD, MHS

Disclosures

Leadership Positions in Professional SocietiesAmerican Society of Hematology (Senior Editor, ASH Self-Assessment Program; guideline development)

Managing Pregnancy in Women with Myeloproliferative Neoplasms

Topics

Reviewing Author