Treating C. difficile Recurrence with Fecal Transplant vs. Antibiotics

Bloodstream infections and hospital length of stay were reduced, and the overall survival rate was higher, with fecal microbiota transplant.

Clostridioides difficile infection (CDI) was originally treated with antimicrobials such as oral vancomycin and metronidazole. CDI has a propensity to recur and lead to complications including blood stream infections (BSIs) and treatment failure. In the past decade, fecal microbiota transplantation (FMT) has been effective in curing CDI and preventing recurrence. Is FMT also effective in reducing incidence of BSI, shortening hospitalization duration, and improving overall survival (OS)?

To find out, investigators conducted a prospective cohort study of 290 hospitalized patients with recurrent CDI. Of these, 109 received FMT and 181 received antibiotics; 52% of FMT recipients and 31% of antibiotic recipients were matched with their respective…

Reviewing Author

Stephen G. Baum, MD

Disclosures

Consultant/Advisory BoardClinical Infectious Diseases

RoyaltiesUpToDate

Editorial BoardsMedical Letter

Stephen G. Baum, MD

Disclosures

Consultant/Advisory BoardClinical Infectious Diseases

RoyaltiesUpToDate

Editorial BoardsMedical Letter

Treating C. difficile Recurrence with Fecal Transplant vs. Antibiotics

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Reviewing Author