Identifying Bleeding Disorders in Adolescents with Heavy Menstrual Bleeding

Von Willebrand disease and qualitative platelet dysfunction were commonly diagnosed in adolescents with HMB.

Hematologists are often involved in the care of adult women with heavy menstrual bleeding (HMB). In addition to managing iron deficiency, they assist in the diagnosis of a bleeding diathesis. However, the prevalence, predictors, and characteristics of bleeding disorders (BDs) in adolescents with HMB are unclear.

To address this knowledge gap, investigators conducted a multicenter, prospective, cohort study of 200 adolescents with HMB. Participants were classified as having anovulatory HMB (cycle length, <21 or >45 days) or ovulatory HMB (if outside anovulatory cycle lengths). The minimum BD workup included assessments of prothrombin time, partial thromboplastin time, fibrinogen, von Willebrand factor (VWF), platelet aggregation, factor IX an…

Reviewing Author

Brady L. Stein, MD, MHS

Disclosures

Leadership Positions in Professional SocietiesAmerican Society of Hematology (Senior Editor, ASH Self-Assessment Program; guideline development)

Brady L. Stein, MD, MHS

Disclosures

Leadership Positions in Professional SocietiesAmerican Society of Hematology (Senior Editor, ASH Self-Assessment Program; guideline development)

Identifying Bleeding Disorders in Adolescents with Heavy Menstrual Bleeding

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Reviewing Author