Suggested β-Lactam Therapeutic Drug Monitoring Targets for Critically Ill Patients

A favorable effect of antibiotic therapy was associated with antibiotic trough concentration/minimum inhibitory concentration of the causative pathogen >1.3.

The bactericidal effect of β-lactam antibiotics is closely related to the time that concentrations are above the minimum inhibitory concentration (fT>MIC) of the causative bacterial pathogen(s) over the dosing interval. It is generally thought that at least 30% to 60% fT>MIC is required for a bactericidal effect, but studies have shown that trough concentrations (fCmin) severalfold above MIC (i.e., 100% fT>MIC) may show better clinical outcomes. To clarify this area of uncertainty, researchers correlated various β-lactam serum levels with the MICs of the causative pathogen and the clinical outcomes of 98 critically ill patients with monomicrobial gram-negative bloodstream infections (Escherichia coli, 29%; Pseudomonas aeruginosa, 19%; Klebs…

Reviewing Author

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Suggested β-Lactam Therapeutic Drug Monitoring Targets for Critically Ill Patients

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Reviewing Author