Loading...
The pathophysiology of infections is determined largely by the innate immune system's response to the pathogen. Symptomatic mucosal candidiasis of the vaginal and oral cavity is driven in part by NLRP3 inflammasome recruitment of inflammatory cells in response to C. albicans hypha formation and Candidalysin (toxin) secretion. Based on previous work showing that glyburide, a sulfonylurea drug used to treat type 2 diabetes mellitus, inhibits inflammasome activation, investigators have now examined drugs in this class for inflammasome inhibition and prevention of IL1-β release in C. albicans infections.
The authors found that the second-generation sulfonylureas glyburide, glisoxepide, gliquidone, and glimepiride demonstrated anti-inflammatory e…