Loading...
Radiofrequency ablation (RFA) is an acceptable alternative to surgery to treat small hepatocellular cancer (HCCs). However, the role of RFA in recurrent HCC is less well-defined.
Investigators from China now report results of a multicenter, open-label, randomized phase III trial in patients who had recurrent HCC with either solitary recurrence ≤5 cm in diameter or 3 or fewer nodules ≤3 cm in diameter after prior partial hepatectomy for HCC. Patients were assigned to undergo repeat hepatectomy or RFA. Of 240 patients randomized, the median age was 50 to 52 years, 89% to 91% were male, 76% to 82% had HCC related to hepatitis B, 78% to 83% had multiple tumors, and 63% to 68% had lesions ≤5 cm.
Overall survival (OS; the primary endpoint) was not …