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Diabetic foot osteomyelitis (DFO) is one of the most problematic infections encountered in the practice of infectious diseases, and lower limb amputation is an all-too-common outcome. Few comparative data are available to define optimal antibiotic therapy, and various regimens are regularly used.
Rifampin has several properties, including the ability to penetrate biofilms and achieve intracellular concentrations within osteoblasts, that make it an attractive option for treatment of osteoarticular infections. To assess its possible benefit as an adjunct therapy for DFO, investigators retrospectively assessed outcomes in patients who received antibiotic treatment for DFO at Veterans Health Administration (VHA) facilities. They compared the rat…