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When Kanner described autistic disturbances of affective contact in 1943, he observed that one of the hallmark clinical features was an “anxiously obsessive desire for the maintenance of sameness.” Many studies since have documented the prevalence of co-occurring psychiatric disorders in patients with autism spectrum disorder (ASD). In this population-based study, investigators leveraged a cohort of 31,220 individuals born from 1976 to 2000 in Olmsted County, Minnesota, to ascertain the prevalence of bipolar disorder, depression, and anxiety disorders in 1014 individuals with ASD, compared with 2028 age- and sex-matched controls.
Incident rates of these disorders by age 30 were as follows:
Bipolar disorder: 7.3% in individuals with ASD and ju…