Both Clindamycin and Gentamicin at Hospital Delivery Carry Risks

Treatment of postpartum endometritis requires broad spectrum antibiotics with excellent anaerobic coverage and minimal toxicity. To assess risk for Clostridioides difficile (C. difficile) infection following clindamycin administration and risk for acute kidney injury following gentamicin administration, investigators queried a U.S. administrative database of delivery admissions among >5 million women.

Among women receiving clindamycin, 0.4% developed C. difficile infection. In adjusted models, risk for such infection was 2.5 times higher in women who received clindamycin than in those who received other antibiotics. Among women receiving gentamicin, 0.24% developed acute kidney injury. Risk for acute kidney injury was also 2.5 times higher a…