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Risk factors for gastric cancer include infection with H. pylori and a family history of gastric cancer. Having a first-degree relative with gastric cancer is associated with a twofold to threefold increased risk for gastric cancer. So, for people in this high-risk category, does eradication of H. pylori reduce risk for gastric cancer?
To answer this question, investigators from Korea performed a single-center, double-blind, placebo-controlled trial in 1676 patients who had a first-degree relative with gastric cancer and endoscopically documented H. pylori infection. The treatment group received amoxicillin, clarithromycin, and lansoprazole twice daily for 7 days, and eradication was confirmed in 551 of 786 participants (70.1%).
During a medi…